Cancer: An underlying cause and what to do about it
Cancer affects one out of five people worldwide. According to date from the American Cancer Society, the cancer incidence rate increased by 4.5% from 2013 to 2018, while the death rate increased by 5%. this clearly indicated that our current mainstream approach to cancer needs to be reconsidered.
People with Cancer
Table 1. American Cancer Society
Cancer — What is it?
Cancer is a disease in which abnormal cells divide uncontrollably and can invade surrounding tissues. Cancer is a disease that affects everyone. Underlying health issues and daily nutrition are important factors in cancer survival and recovery.
What do Cancer cells feed on?
It is untrue to say that cancer is only a genetic illness, contrary to current doctrine. The rate might range from 1.3 to 10% depending on the type of cancer. Cancer Cell Growth Cancer has an increased need for glucose. Cancer cells rely on sugar to support their rapid growth. This knowledge is used in PET scans to image cancer using radioactive glucose.
Glutamine, the most abundant amino protein in blood (plasma), is also used by cancer cells. Glutamine starvation is used by many as an adjunct to their therapy.
Discovering the Root of Cancer
In 2022, techniques are being examined by cancer experts. Although it is generally acknowledged that cancer is caused by mutations, the actual query is, what kind of environment can cause the body to acquire cancer?
Scientists at Tulane University in Louisiana swapped the nuclei of healthy fertilized frog eggs with those of cancerous frog cells. None of the frogs developed cancer.
Research on genetic cancer is being expanded. According to their hypothesis, if cancer is a hereditary disorder (governed by the growth of cancer in the DNA of cell nuclei), then the frogs that grew would have developed cancer too.
Next, researchers at the Institute of Cancer Research in Pennsylvania created clones of healthy mice from the nucleus of a cancer cell and came to the conclusion that genetic abnormalities are not the cause of cancer.
One of the major causes of cancer treatment failure is resistance to cell death caused by anticancer drugs. The mitochondria, the cell's powerhouse, can also suffer from metabolic dysfunction, which has been linked to the development and progression of cancer.
If cancer isn’t solely a genetic disease, where does the root of cancer lie?
When we consider the findings of another group of scientists at the Baylor College of Medicine in Texas, the answer begins to become clear. They found that inserting normal mitochondria into cancerous cells reversed cancer in the cell.
Then, at UAM University in Madrid, another group of scientists discovered that normal mitochondria could suppress cancer despite the presence of a cell nucleus that would normally generate cancer.
Damage to healthy mitochondria in cells, as well as immune system malfunctions, can result in roaming malignant cells that avoid detection and elimination by the immune system. It is also important to note that immunodeficiency is more prevalent in lymphoma and leukemia than in other cancers.
The focus on glucose intake and Keto nutrition
Cancer-associated malnutrition can have several detrimental effects, including as a poor prognosis, lower survival rates, increased therapy toxicity, and the release of chemicals by the cancer that can result in cancer cachexia. Therefore, it is good to be knowledgeable about cancer-related malnutrition and how to treat it.
How to Support the Health of Your Mitochondria and Your Immune System
Mitochondrial and Cancer Support - GcMAF Dr. Marco Ruggiero, a molecular scientist, and oncologist, studied nutrition, health, and mitochondrial dysfunction and found combinations that support healthy mitochondrial activity.
Ruggiero and his research team measured tumor size in conjunction with a low-carbohydrate, high-protein diet and supplemented with highly concentrated probiotics that naturally include GcMAF, Vitamin D3, and Omega 3. They also reported a 25% in tumor size decrease in volume.
Ruggiero concluded, “We are very well-aware that the word "cancer" comprises hundreds of different diseases, each one with different etiology, pathogenesis, prognosis, and targeted treatment; that each cancer patient, even when histology, grade and stage are the same, may have different sets of mutations and that, essentially, every cancer is unique.
Combining nutrients and their delivery can completely affect the body in different ways stresses Ruggiero. “It is not as to compare apples to oranges, but rather as to compare apples to French fries; both are edible, but this may be the only quality they have in common. This has led onto more research and people taking GcMAF, alongside doing the Keto diet for cancer support, tumors, ageing, macrophage health, other healthy immune cells, cell health, mitochondria re-conditioning to plasma cell bone marrow infiltration for immunity.
Curcumin supports healthy mitochondrial functions and biogenesis. Ultra-Complex curcumin preparations support normal physiological function and high levels of inflammation in the body and brain. Curcumin supports a strong and balanced immune system, the liver, intestinal health, body and joint comfort and mobility.
Boswellia is world renown and was one of the first plant materials recognized in the Bible. Frankincense also known as Boswellia, supports healthy mitochondrial functions and triggers cancer cell death. Boswellia supports a strong and balanced immune system.
AMINO Acids are the body's protein building blocks. Eight essential amino acids are necessary for sustenance and prevent the body from cannibalizing its own muscles. For immunity, the immune system depends on the blood, lymph, lymphatic system, muscles, and bones. If eating protein is challenging for you for whatever reason, it is imperative that you continue to include amino acids in your diet. This is done to keep you in ketosis so that you can keep your muscles as healthy as possible while starving cancer cells of sugar.
Oral and nutritional supplements are regarded as a cornerstone in malnutrition regimen approaches.
Intermittent Fasting. Calorie restriction stimulates the growth of new mitochondria (biogenesis) and strengthens existing mitochondria through stimulating longevity Sirtuins in the body to redirect metabolism.
Adopt the Ketogenic Diet Daily. Adopt a ketogenic (low glucose) diet. The ketones produced have a pro-immunogenic effect. Our approach then is to naturally support the health of your mitochondria and your immune system, and to stress any cancer cells by adopting a ketogenic (low glucose) diet and to drink green tea through the day.
The cornerstone of this strategy is the "intermittent fasting ketogenic diet," which, when carefully adhered to, seems to considerably improve results. Cancer patients are concerned about dieting because they fear further weight loss The typical diet is heavy in calories and primarily composed of carbs. In mice models of colon cancer, Beck and Tisdale looked at how KD usage delayed cachexia. They discovered that dieting had the additional benefit of shrinking tumor size and was more effective than insulin at reversing weight loss. Additionally, Tisdale and associates discovered that KD usage in cachectic cancer patients can encourage weight gain.
• We advise measuring your blood ketone levels with a finger prick ketone meter, every morning before eating. Aim for 3.0 to 6.0 mmol/L.
• The recommended Ketogenic Diet involves limiting carbohydrates to 12 grams a day (basically only eating green salads) whilst increasing the consumption of foods high in fat (avocados, olive oil, coconut oil, cream) and moderating intake of protein (Up to 100 grams a day) or use a replacement with eight essential aminos to suit your protocol.
• This reduces the blood glucose and produces ketones to fuel healthy cells. In addition, ketones have anti-inflammatory and pro-immunogenic properties.
Vitamins and minerals are supplementary to and not a replacement for a balanced diet. If symptoms persist, see your healthcare professional. None of our articles are intended to diagnose, treat, cure, or prevent any disease.
3. Meng, Xiangyu et al. 12 April 2022. Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy. Elsevier, Vol 15, June 2022, pp. 222-234.
4. Jiang J, Srivastava S, Zhang J. Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? Cancers (Basel). 2019 Jun 11;11(6):804. doi: 10.3390/cancers11060804. PMID: 31212591; PMCID: PMC6627209.
5. Choi YK, Park KG. Targeting Glutamine Metabolism for Cancer Treatment. Biomol Ther (Seoul). 2018 Jan 1;26(1):19-28. doi: 10.4062/biomolther.2017.178. PMID: 29212303; PMCID: PMC5746034.
6. McKinnell RG, Deggins BA, Labat DD. Transplantation of pluripotential nuclei from triploid frog tumors. Science. 1969 Jul 25;165(3891):394-6. doi: 10.1126/science.165.3891.394. PMID: 5815255.
7. Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3585-9. doi: 10.1073/pnas.72.9.3585. PMID: 1059147; PMCID: PMC433040.
8. Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJ. Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One. 2013 May 9;8(5): e61747. doi: 10.1371/journal.pone.0061747. Erratum in: PLoS One. 2019 Aug 22;14(8): e0221671. PMID: 23671572; PMCID: PMC3650012.
9. Cruz-Bermúdez A, Vallejo CG, Vicente-Blanco RJ, Gallardo ME, Fernández-Moreno MÁ, Quintanilla M, Garesse R. Enhanced tumorigenicity by mitochondrial DNA mild mutations. Oncotarget. 2015 May 30;6(15):13628-43. doi: 10.18632/oncotarget.3698. Erratum in: Oncotarget. 2020 Mar 17;11(11):1006. PMID: 25909222; PMCID: PMC4537038.
10. Seyfried TN, Chinopoulos C. Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory? Metabolites. 2021 Aug 25;11(9):572. doi: 10.3390/metabo11090572. PMID: 34564387; PMCID: PMC8467939.
11. Solaini G, Sgarbi G, Baracca A. Oxidative phosphorylation in cancer cells. Biochim Biophys Acta. 2011 Jun;1807(6):534-42. doi: 10.1016/j.bbabio.2010.09.003. Epub 2010 Sep 16. PMID: 20849810.
12. Shurin MR. Cancer as an immune-mediated disease. Immunotargets Ther. 2012 Jun 13; 1:1-6. doi: 10.2147/ITT.S29834. PMID: 27471681; PMCID: PMC4934149.
13. Vajdic CM, Mao L, van Leeuwen MT, et al. Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency? Blood. 2010 Aug;116(8):1228-1234. DOI: 10.1182/blood-2010-03-272351. PMID: 20466855.
14. Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, Fuleihan R, Garabedian E, Lugar P, Ochs HD, Bonilla FA, Buckley RH, Sullivan KE, Ballas ZK, Cunningham-Rundles C, Segal BH. Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018 Mar;141(3):1028-1035. doi: 10.1016/j.jaci.2017.05.024. Epub 2017 Jun 9. PMID: 28606585; PMCID: PMC5723251.
15. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hütterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Mühlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017 Feb;36(1):11-48. doi: 10.1016/j.clnu.2016.07.015. Epub 2016 Aug 6. PMID: 27637832.
Chi Childs CE, Calder PC, Miles EA. Diet and Immune Function. Nutrients. 2019 Aug;11(8):1933. doi: 10.3390/nu11081933. Full text: https://www.mdpi.com/2072-6643/11/8/1933/html
18. Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, Leeuwenburgh C, Mattson MP. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring). 2018 Feb;26(2):254-268. doi: 10.1002/oby.22065. Epub 2017 Oct 31. PMID: 29086496; PMCID: PMC5783752.
19. Pacini, Stefania & Ruggiero, Marco. (2019). Color Doppler Evaluation of Isovolumetric Relaxation Time and of Signals Arising from Axons of the Median Nerve as a Means to Evaluate Mitochondrial Functionality in the Context of Immunotherapy of Cancer and Chronic Conditions Associated with Mitochondrial Dysfunction. American Journal of Immunology. 15. 22-32. 10.3844/ajisp.2019.22.32.
Effects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue Syndrome. Smith R, Thyer L, Ward E, Meacci E, Branca J, Morucci G, Gulisano M, Ruggiero M, Pacini A, Paternostro F, Lorenzo D, Noakes D, and Pacini S. 6 Nov 2013, American Journal of Immunology, pp. 120-129, https://doi.org/10.3844/ajisp.2013.120.129.
20. Rationale for the design of a novel tool for immunotherapy. Ruggiero M, Pacini S. Switzerland: s.n., 27 Aug 2018, Integrative Cancer Science and Therapeutics, pp. 1-5, https://doi.org/10.15761/ICST.1000285.
21. Antonucci, N., Pacini, S. & Ruggiero, M. (2019). Use of an Extremely Biodiverse Probiotic and a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio and of Plasma Cell Bone Marrow Infiltration in a Case of Multiple Myeloma. American Journal of Immunology, 15(1), 5-9. https://doi.org/10.3844/ajisp.2019.5.9
22. Ruggiero M, Pacini S. A Novel potential Adjuvant for Cancer Vaccines. Madridge J Vaccines. 2018; 2(1): 57-61. doi: 10.18689/mjv-1000112
23. Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames. Stefania Pacini, Marco Ruggiero. s.l. : Biorxiv, 6 Aug 2019. https://www.biorxiv.org/content/10.1101/714154v2.full.
24. Dakota N. Jackson & Arianne L. Theiss (2020) Gut bacteria signalling to mitochondria in intestinal inflammation and cancer, Gut Microbes, 11:3, 285-304.
25. Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System. Stefania Pacini and Marco Ruggiero / American Journal of Immunology 2017, 13 (2): 107.113 DOI: 10.3844/ajisp.2017.107.113 https://thescipub.com/pdf/ajisp.2017.107.113.pdf
26. Thyer L, Ward E, Smith R, Fiore MG, Magherini S, Branca JJ, Morucci G, Gulisano M, Ruggiero M, Pacini S. A novel role for a major component of the vitamin D axis: vitamin D binding protein-derived macrophage activating factor induces human breast cancer cell apoptosis through stimulation of macrophages. Nutrients. 2013 Jul 8;5(7):2577-89. doi: 10.3390/nu5072577. PMID: 23857228; PMCID: PMC3738989.
27. Soto-Urquieta, María & López-Briones, Sergio & Perez-Vazquez, Victoriano & Saavedra-Molina, Alfredo & Gonzalez, Angelica & Ramírez-Emiliano, Joel. (2014). Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice. Biological research. 47. 10.1186/0717-6287-47-74.
28. Bose S, Panda AK, Mukherjee S, Sa G. Curcumin and tumor immune editing: resurrecting the immune system. Cell Div. 2015 Oct 12; 10:6. doi: 10.1186/s13008-015-0012-z. PMID: 26464579; PMCID: PMC4603973.
29. Liu JJ, Nilsson A, Oredsson S, Badmaev V, Zhao WZ, Duan RD. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 2002 Dec;23(12):2087-93. doi: 10.1093/carcin/23.12.2087. PMID: 12507932.
30. Qurishi Y, Hamid A, Sharma PR, Wani ZA, Mondhe DM, Singh SK, Zargar MA, Andotra SS, Shah BA, Taneja SC, Saxena AK. PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models. Future Oncol. 2012 Jul;8(7):867-81. doi: 10.2217/fon.12.68. PMID: 22830406.
31. Beghelli D, Isani G, Roncada P, Andreani G, Bistoni O, Bertocchi M, Lupidi G, Alunno A. Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts. Oxid Med Cell Longev. 2017; 2017:7468064. doi: 10.1155/2017/7468064. Epub 2017 Mar 13. PMID: 28386311; PMCID: PMC5366763.