Cancer – The underlying cause and what to do about it?
Cancer Statistics (USA)
Data from the American Cancer Society, reports that the incidence of cancer from 2013 to 2018 has increased by 4.5% and yet the death rate has increased by 5%. This clearly indicates that our current mainstream approach to cancer does not work. We are not winning the war against cancer and this indicates that the current dogma, that cancer is a genetic disease, is incorrect.
Cancer – What is it?
Cancer is a disease in which abnormal cells divide without control and can invade nearby tissues.
What do Cancer cells feed on?
Cancer cells have an increased number of insulin receptors which means that they have an increased requirement for Glucose. This knowledge is used to image cancer with radioactive glucose and PET or CAT scans. Cancer cells also feed on Glutamine, the most abundant amino acid in plasma (1).
Discovering the Root of Cancer
Scientists at Tulane University, in Louisiana, transplanted the nuclei of frog cancer cells, into and replaced the nuclei of healthy fertilised frog eggs. Of the frogs that grew, none of them had cancer. If cancer was a genetic disease, ruled by the oncogenes in the nuclei, then the frogs that grew would have developed cancer (2).
Next, scientists at the Institute of Cancer Research, in Pennsylvania, cloned healthy mice from the nucleus of a tumour cell and thereby concluded, that it was not possible that genetic mutations are driving cancer (3).
Later studies by different scientists support the same conclusion, that cancer is NOT a genetic disease. Where then does the root of cancer lie?
The answer starts to become clear when we consider the results of another group of scientists at the Baylor College of Medicine in Texas. They placed normal mitochondria into cancerous cells and found this reversed cancer in the cell (4). Note: Mitochondria are the organelles of your cells in which the processes of respiration and energy production occur.
Then another group of scientists at UAM University in Madrid, found normal mitochondria can suppress cancer despite the presence of cell nucleus that would normally generate cancer (5).
All this clearly indicates that cancer is caused by damage to the mitochondria in cells and that healthy mitochondria can reverse cancer; however, cancer is also a manifestation of malfunctions in immunity, as malignant cells manage to escape recognition and elimination by the immune system (6).
It is also worth noting that immunodeficiency plays a larger role in lymphoma and leukaemia than it does with other cancers (7) (8).
How to Support the Health of Your Mitochondria and Your Immune System
- imuno® superior immune & mitochondrial support
imuno® supports healthy mitochondrial functions and biogenesis (10) (11).
imuno® supports a strong and balanced immune system (12) (13) (14) (15).
- Bravo Probiotic
Bravo Probiotic supports healthy mitochondrial functions (16) (17).
Bravo Probiotic supports a strong and balanced immune system (13) (16) (18) (19).
- UltraCur Curcumin
Curcumin supports healthy mitochondrial functions and biogenesis (20) (21).
Curcumin supports a strong and balanced immune system (22).
- Boswell Boswellia
Boswellia supports healthy mitochondrial functions (23) (24).
Boswellia supports a strong and balanced immune system (25).
- Intermittent Fasting
Intermittent fasting (calorie restriction) stimulates the growth of new mitochondria (biogenesis) and strengthens existing mitochondria (9).
- Ketogenic Diet
Adopt a ketogenic (low glucose) diet. The ketones produced have a pro-immunogenic effect.
- Green Tea (EGCG)
Evidence suggests that drinking green tea (EGCG) through the day restricts the bodies use of glutamine (1).
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2. Transplantation of pluripotential nuclei from triploid frog tumors. McKinnell RG, Deggins BA, Labat DD. 3891, New Orleans : Science, 25 Jul 1969, Vol. 165, pp. 394-396, https://www.ncbi.nlm.nih.gov/pubmed/5815255.
3. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Mintz B, Illmensee K. 9, s.l. : Proc Natl Acad Sci U S A, Sept 1975, Vol. 72, pp. 3585–3589, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC433040/.
4. Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJ. 5, Houston : s.n., 9 May 2013, PLoS One, Vol. 8, pp. e61747, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650012/.
5. Enhanced tumorigenicity by mitochondrial DNA mild mutations. Cruz-Bermúdez A, Vallejo CG, Vicente-Blanco RJ, Gallardo ME, Fernández-Moreno MÁ, Quintanilla M, Garesse R. 15, Madrid : s.n., 30 May 2015, Oncotarget, Vol. 6, pp. 13628-43, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537038/.
6. Cancer as an immune-mediated disease. Shurin, Michael R. 1, Pittsburgh : Dove Press, 13 June 2012, Immunotargets and Therapy Journal, Vol. 1, pp. 1-6, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934149/.
7. Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency? Claire M. Vajdic, Limin Mao, Marina T. van Leeuwen, Philippa Kirkpatrick, Andrew E. Grulich and Sean Riminton. Sydney : American Society of Hematology, 2010, Blood, Vol. 116, pp. 1228-1234, https://doi.org/10.1182/blood-2010-03-272351.
8. Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. P C. Mayor, K H. Eng, K L. Singel, S I. Abrams, K Odunsi, K B. Moysich, R Fuleihan, E Garabedian, P Lugar, H D. Ochs, F A. Bonilla, R H. Buckley, K E. Sullivan, Z K. Ballas, C Cunningham-Rundles, B H. Segal. 3, New York : American Academy of Allergy, Asthma, and Immunology, March 2018, J Allergy Clin Immunol, Vol. 141, pp. 1028-1035, https://dx.doi.org/10.1016/j.jaci.2017.05.024.
9. Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting. Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, Christiaan Leeuwenburgh, and Mark P. Mattson. 2, Feb 2018, Obesity (Silver Spring), Vol. 26, pp. 254–268, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/.
10. Color Doppler evaluation of Isovolumetric Relaxation Time and of signals arising from axons of the median nerve as a means to evaluate mitochondrial functionality. Ruggiero, Stefania Pacini and Marco. 2019, American Journal of Immunology.
11. Effects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue Syndrome. Smith R, Thyer L, Ward E, Meacci E, Branca J, Morucci G, Gulisano M, Ruggiero M, Pacini A, Paternostro F, Lorenzo D, Noakes D, and Pacini S. 6 Nov 2013, American Journal of Immunology, pp. 120-129, https://doi.org/10.3844/ajisp.2013.120.129.
12. Rationale for the design of a novel tool for immunotherapy. Ruggiero M, Pacini S. Switzerland : s.n., 27 Aug 2018, Integrative Cancer Science and Therapeutics, pp. 1-5, https://doi.org/10.15761/ICST.1000285.
13. Use of an Extremely Biodiverse Probiotic & a Supplement Based on Microbial Chondroitin Sulfate is Associated with a Significant Decrease of Serum Free Kappa Light Chains as well as a Trend Toward Normalization of Kappa/Lambda Ratio & of Plasma Cell Bone M. Antonucci N, Pacini S, Ruggiero M. 18 Jun 2019, American Journal of Immunology, p. . https://thescipub.com/abstract/10.3844/ofsp.12602.
14. A Novel potential Adjuvant for Cancer Vaccines. S, Ruggiero M and Pacini. 1, 29 Sept 2018, Madridge Journal of Vaccines, Vol. 2, pp. 58-62. https://doi.org/10.18689/mjv-1000112.
15. Clinical Experience of Integrative Autism treatment with a Novel type of Immunotherapy. Antonucci N, Pacini S, Ruggiero M. 1, Italy : s.n., 22 Feb 2019, Madridge Journal of Vaccines, Vol. III, pp. 71-76, https://doi.org/10.18689/mjv-1000116.
16. Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames. Stefania Pacini, Marco Ruggiero. s.l. : Biorxiv, 6 Aug 2019, p. . https://www.biorxiv.org/content/10.1101/714154v2.full.
17. Gut bacteria signaling to mitochondria in intestinal inflammation and cancer. Theiss, Dakota N. Jackson & Arianne L. Texas : Taylor & Francis, 26 Mar 2019, Gut Microbes, p. . https://doi.org/10.1080/19490976.2019.1592421.
18. Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System. Ruggiero, Stefania Pacini and Marco. 2, s.l. : Science Publications, 19 Jan 2017, American Journal of Immunology, Vol. 13, pp. 107-113, https://thescipub.com/abstract/10.3844/ajisp.2017.107.113.
19. Macrophages of the mucosa-associated lymphoid tissue (MALT) as key elements of the immune response to vitamin D binding protein-macrophage activating factor. Stefania Pacini, Tiziana Punzi, Gabriele Morucci, Marco Ruggiero. s.l. : Italian Journal of Anatomy and Embryology, 2011, Vol. 116, pp. . http://dx.doi.org/10.13128/IJAE-10160.
20. Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice. María G Soto-Urquieta, Sergio López-Briones, Victoriano Pérez-Vázquez, Alfredo Saavedra-Molina, Gloria A González-Hernández, and Joel Ramírez-Emiliano. 1, 22 Dec 2014, Biological Research, Vol. 47, pp. 74, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289591/.
21. Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs. Marcos Roberto de Oliveira, Fernanda Rafaela Jardim, William N. Setzer, Seyed Mohammad Nabavi, Seyed Fazel Nabavi. 5, 1 May 2016, Biotechnology Advances, Vol. 34, pp. 813-826, https://doi.org/10.1016/j.biotechadv.2016.04.004.
22. Curcumin and tumor immune-editing: resurrecting the immune system. Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee, and Gaurisankar Sa. 6, 12 Oct 2015, Cell Division, Vol. 10, p. . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603973/.
23. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Jian-Jun Liu, Åke Nilsson, Stina Oredsson, Vladimir Badmaev, Wan-Zhou Zhao, Rui-Dong Duan. 12, 1 Dec 2002, Carcinogenesis, Vol. 23, pp. 2087–2093, https://doi.org/10.1093/carcin/23.12.2087.
24. PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models. Yasrib Qurishi, Abid Hamid, Parduman R Sharma, Zahoor Ahmad Wani, Dilip M Mondhe, Shashank K Singh, Mohmmad Afzal Zargar, Samar S Andotra, Bhahwal Ali Shah, Subhash C Taneja & Ajit Kumar Saxena. 7, 25 Jul 2012, Future Oncology, Vol. 8, p. . https://doi.org/10.2217/fon.12.68.
25. Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts. Daniela Beghelli, Gloria Isani, Paola Roncada, Giulia Andreani, Onelia Bistoni, Martina Bertocchi, Giulio Lupidi, and Alessia Alunno. 13 Mar 2017, Oxidative Medicine and Cellular Longevity, p. . https://dx.doi.org/10.1155/2017/7468064.